A selective

SSR 240612 – 10 mg

Brand:
Cayman
CAS:
464930-42-5
Storage:
-20
UN-No:
Non-Hazardous - /

SSR 240612 is a selective, non-peptide antagonist of the bradykinin B1 receptor (Kis = 0.48-0.73 and 358-481 nM for B1 and B2 receptors, respectively).{45045} It inhibits the contraction of rabbit aorta and rat ileum induced by the B1 receptor agonist des-Arg9-bradykinin (des-Arg9-BK) ex vivo in a concentration-dependent manner. SSR 240612 (0.3 mg/kg) reduces tissue damage and neutrophil accumulation in a rat model of splanchnic artery occlusion/reperfusion-induced intestinal injury and inhibits des-Arg9-BK-induced paw edema in mice when administered orally at doses of 3 and 10 mg/kg or intraperitoneally at doses of 0.3 and 1 mg/kg. SSR 240612 (10 mg/kg per day) reduces fibrosis in a unilateral ureteral obstruction mouse model of kidney fibrosis.{45046} It also reduces mean arterial blood pressure in two rat models of hypertension when administered at doses of 5 and 10 mg/kg and reduces plasma glucose and insulin levels in a glucose-fed rat model of insulin resistance when administered at a dose of 10 mg/kg per day.{45047,45048} SSR 240612 also exhibits analgesic properties in several rodent models of hyperalgesia.{45045}  

 

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SKU: 25544 - 10 mg Category:

Description

A selective, non-peptide bradykinin B1 receptor antagonist (Kis = 0.48-0.73 and 358-481 nM for B1 and B2 receptors, respectively); inhibits the contraction of rabbit aorta and rat ileum induced by des-Arg9-BK ex vivo; reduces tissue damage and neutrophil accumulation in a rat model of splanchnic artery occlusion/reperfusion-induced intestinal injury; inhibits des-Arg9-BK-induced paw edema in mice at 3 and 10 mg/kg; reduces fibrosis in a unilateral ureteral obstruction mouse model of kidney fibrosis; reduces mean arterial blood pressure in two rat models of hypertension; reduces plasma glucose and insulin levels in a glucose-fed rat model of insulin resistance; exhibits analgesic properties in several rodent models of hyperalgesia

Formal name: (3R)-3-(1,3-benzodioxol-5-yl)-N-[(6-methoxy-2-naphthalenyl)sulfonyl]-β-alanyl-4-[[(2R,6S)-2,6-dimethyl-1-piperidinyl]methyl]-N-methyl-N-(1-methylethyl)-D-phenylalaninamide, monohydrochloride

Synonyms: 

Molecular weight: 793.4

CAS: 464930-42-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Neuroscience|Pain Research

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