Description
An HDAC6 inhibitor (IC50 = 12 nM); selective for HDAC6 over HDAC1, -4, -5, -7, -8, -9, and -11 (IC50s = 1.39, 19.5, 6.91, 8.34, 1.23, 38.2, and 5.12 µM, respectively); inhibits HDAC6 in, but does not induce cell death of, human PC3 prostate, 5637 and T24 bladder, and murine SM1 melanoma cells in vitro from 0.1-25 µM; decreases PD-L1 protein levels in SM1 cells at 5 µM; reduces tumor growth and increases the number of intratumoral CD8+, CD4+, and NK T cells in an SM1 murine melanoma model
Formal name: 5-[2-[(3,4-dichlorobenzoyl)amino]ethyl]-N-hydroxy-3-isoxazolecarboxamide
Synonyms:
Molecular weight: 344.2
CAS: 2245942-72-5
Purity: ≥98%
Formulation: A crystalline solid
