A SIRT1 activator; increases renal SIRT1 activity and protein levels and decreases acetylation of p53 in a mouse model of STZ-induced diabetes

SRT 2104 – 5 mg

Brand:
Cayman
CAS:
1093403-33-8
Storage:
-20
UN-No:
Non-Hazardous - /

SRT 2104 is an activator of sirtuin 1 (SIRT1).{42917} It increases renal SIRT1 activity and protein levels and decreases acetylation of the SIRT1 substrate p53 in a mouse model of diabetes induced by streptozotocin (STZ; Item No. 13104), as well as in non-diabetic control animals, when administered at a dose of approximately 100 mg/kg in the diet. SRT 2104 also decreases renal levels of inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS), and malondialdehyde (MDA), as well as the fibrotic markers TGF-β1 and CTGF and the inflammatory markers PAI-1 and VCAM-1, in STZ-induced diabetic mice. SRT 2104 (0.5% in the diet) increases lifespan, improves motor function in the balance beam test, and reduces atrophy of the neocortex in the N171-82Q mouse model of Huntington’s disease.{42918}  

 

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Description

A SIRT1 activator; increases renal SIRT1 activity and protein levels and decreases acetylation of p53 in a mouse model of STZ-induced diabetes, as well as in non-diabetic control animals, at 100 mg/kg in the diet; decreases renal levels of iNOS, ROS, and MDA, as well as the fibrotic markers TGF-β1 and CTGF and the inflammatory markers PAI-1 and VCAM-1, in STZ-induced diabetic mice; increases lifespan, improves motor function in the balance beam test, and reduces atrophy of the neocortex in the N171-82Q mouse model of Huntington’s disease at 0.5% in the diet

Formal name: 4-methyl-N-[2-[3-(4-morpholinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(3-pyridinyl)-5-thiazolecarboxamide

Synonyms: 

Molecular weight: 516.6

CAS: 1093403-33-8

Purity: ≥98%

Formulation: A crystalline solid

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