Description
A SIRT1 activator; increases renal SIRT1 activity and protein levels and decreases acetylation of p53 in a mouse model of STZ-induced diabetes, as well as in non-diabetic control animals, at 100 mg/kg in the diet; decreases renal levels of iNOS, ROS, and MDA, as well as the fibrotic markers TGF-β1 and CTGF and the inflammatory markers PAI-1 and VCAM-1, in STZ-induced diabetic mice; increases lifespan, improves motor function in the balance beam test, and reduces atrophy of the neocortex in the N171-82Q mouse model of Huntington’s disease at 0.5% in the diet
Formal name: 4-methyl-N-[2-[3-(4-morpholinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(3-pyridinyl)-5-thiazolecarboxamide
Synonyms:
Molecular weight: 516.6
CAS: 1093403-33-8
Purity: ≥98%
Formulation: A crystalline solid