Description
An inhibitor of ferroptosis; inhibits erastin-induced ferroptosis in HT-1080 and NIH3T3 cells at 1 μM; prevents renal tubular damage and prevents increases in serum levels of urea and creatine in a mouse model of renal IRI at 2 mg/kg; increases the levels of GPX4, xCT, and GSH and decreases levels of IL-1β, TNF-α, ICAM-1, and 4HNE in injured spinal cord epicenters in a rat model of spinal cord injury at 15 mg/kg; increases tissue sparing and improves locomotor recovery in the same model
Formal name: 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-benzoic acid, 1,1-dimethylethyl ester
Synonyms:
Molecular weight: 432.6
CAS: 1793052-96-6
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Immunology & Inflammation||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione
