An inhibitor of ferroptosis; inhibits erastin-induced ferroptosis in HT-1080 and NIH3T3 cells at 1 μM; prevents renal tubular damage and prevents increases in serum levels of urea and creatine in a mouse model of renal IRI at 2 mg/kg; increases the levels of GPX4

SRS16-86 – 1 mg

Brand:
Cayman
CAS:
1793052-96-6
Storage:
-20
UN-No:
Non-Hazardous - /

SRS16-86 is an inhibitor of ferroptosis.{43387} It inhibits ferroptosis induced by erastin (Item No. 17754) in HT-1080 and NIH3T3 cells when used at a concentration of 1 μM. SRS16-86 (2 mg/kg) prevents renal tubular damage and increases in serum levels of urea and creatine in a mouse model of renal ischemia-reperfusion injury (IRI). In a rat model of spinal cord injury, SRS16-86 (15 mg/kg) increases the levels of glutathione peroxidase 4 (GPX4), system xc- cystine/glutamate transporter (xCT), and glutathione (GSH) and decreases levels of IL-1β, TNF-α, ICAM-1, and the lipid peroxidation marker 4-hydroxy nonenal (4HNE) in injured spinal cord epicenters.{43841} It also increases tissue sparing and improves locomotor recovery in the same model.  

 

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SKU: 26752 - 1 mg Category:

Description

An inhibitor of ferroptosis; inhibits erastin-induced ferroptosis in HT-1080 and NIH3T3 cells at 1 μM; prevents renal tubular damage and prevents increases in serum levels of urea and creatine in a mouse model of renal IRI at 2 mg/kg; increases the levels of GPX4, xCT, and GSH and decreases levels of IL-1β, TNF-α, ICAM-1, and 4HNE in injured spinal cord epicenters in a rat model of spinal cord injury at 15 mg/kg; increases tissue sparing and improves locomotor recovery in the same model

Formal name: 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-benzoic acid, 1,1-dimethylethyl ester

Synonyms: 

Molecular weight: 432.6

CAS: 1793052-96-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Immunology & Inflammation||Research Area|Neuroscience||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Lipid Peroxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen|Gluthathione Peroxidase||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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