A ferroptosis inhibitor and a derivative of ferrostatin-1; inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM); inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2 µM; protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia at 100 nM; increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease; increases production of ROS in L. major promastigotes at 3 µM; is toxic to L. major promastigotes (LD50 = 3.34 µM)

SRS11-92 – 10 mg

Brand:
Cayman
CAS:
1467047-25-1
Storage:
-20
UN-No:
Non-Hazardous - /

SRS11-92 is a ferroptosis inhibitor and a derivative of ferrostatin-1 (Item No. 17729).{28857} It inhibits ferroptotic cell death induced by erastin (Item No. 17754) in HT-1080 human fibrosarcoma cells (EC50 = 6 nM). SRS11-92 (2 µM) inhibits iron-induced cell death in isolated mouse kidney proximal tubules, and fully protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia when used at a concentration of 100 nM. It also increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease in a concentration-dependent manner. SRS11-92 (3 µM) increases production of reactive oxygen species (ROS) in L. major promastigotes in a time-dependent manner.{42388} It is selectively toxic to L. major promastigotes (LD50 = 3.34 µM) over U2OS human osteoblasts, RAW 264.7 macrophages, and intraperitoneal macrophages when used at a concentration of 80 µM.  

 

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SKU: 25689 - 10 mg Category:

Description

A ferroptosis inhibitor and a derivative of ferrostatin-1; inhibits ferroptotic cell death induced by erastin in HT-1080 human fibrosarcoma cells (EC50 = 6 nM); inhibits iron-induced cell death in isolated mouse kidney proximal tubules at 2 µM; protects rat oligodendrocytes from cystine deprivation-induced cell death in an in vitro model of periventricular leukomalacia at 100 nM; increases survival of medium spiny neurons in rat corticostriatal brain slices in an in vitro model of Huntington’s disease; increases production of ROS in L. major promastigotes at 3 µM; is toxic to L. major promastigotes (LD50 = 3.34 µM)

Formal name: 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-benzoic acid, ethyl ester

Synonyms:  AA9

Molecular weight: 352.5

CAS: 1467047-25-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Research Area|Cancer|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen

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