A liver-specific inverse agonist of the two LXR isoforms

SR9238 – 5 mg

Brand:
Cayman
CAS:
1416153-62-2
Storage:
-20
UN-No:
Non-Hazardous - /

The liver X receptors (LXRs) are nuclear receptors that act as ligand-dependent transcription factors.{24819} They modulate lipid, cholesterol, and carbohydrate metabolism and homeostasis. SR9238 is an inverse agonist of the two LXR isoforms, LXRα and LXRβ (IC50s = 214 and 43 nM, respectively).{30144} It displays liver specificity in vivo, with little action at peripheral LXR. SR9238 suppresses hepatic lipogenesis, inflammation, lipid accumulation, and fibrosis in mouse models of non-alcoholic steatohepatitis.{30144,30145} It also reduces plasma cholesterol levels in diet-induced obese mice.{30144}  

 

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Description

A liver-specific inverse agonist of the two LXR isoforms, LXRα and LXRβ (IC50s = 214 and 43 nM, respectively); suppresses hepatic lipogenesis, inflammation, lipid accumulation, and fibrosis in mouse models of non-alcoholic steatohepatitis

Formal name: 5-[[[[3′-(methylsulfonyl)[1,1′-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylic acid, ethyl ester

Synonyms: 

Molecular weight: 595.7

CAS: 1416153-62-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation

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