Description
A REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERBα and REV-ERBβ (IC50s = 790 and 560 nM, respectively); alters the circadian pattern of expression of several metabolic genes in liver, skeletal muscle, and adipose tissue of mice, resulting in increased energy expenditure
Formal name: 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-N-pentyl-1-pyrrolidinecarboxamide
Synonyms:
Molecular weight: 479
CAS: 1379686-29-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms