Description
A REV-ERB agonist that increases the constitutive repression of genes regulated by REV-ERBα and REV-ERBβ (IC50s = 670 and 800 nM, respectively); decreases circadian locomotor activity during the dark phase and alters the expression pattern of core clock genes and metabolic genes; improves dyslipidemia and hyperglycemia in diet-induced obese mice
Formal name: 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester
Synonyms: REV-ERB Agonist II
Molecular weight: 437.9
CAS: 1379686-30-2
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms