A derivative of GABA that acts as an antagonist of GABAA receptors (Ki = 74-150 nM); elicits seizures when administered intravenously in mice; effective against GABAA receptor isoforms from mice

SR 95531 (hydrobromide) – 5 mg

Brand:
Cayman
CAS:
104104-50-9
Storage:
-20
UN-No:
Non-Hazardous - /

SR 95531 is a derivative of γ-aminobutyric acid (GABA) that acts as an antagonist of GABAA receptors (Ki = 74-150 nM).{23068,23065,23067} When administered intravenously, it elicits seizures in mice.{23068} SR 95531 differs in action from bicuculline (Item No. 11727) in that it antagonizes GABA-induced chloride currents but not those induced by pentobarbitone.{23064} It is effective against GABAA receptor isoforms from mice, rats, and humans.{23068,23065,23063}  

 

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Description

A derivative of GABA that acts as an antagonist of GABAA receptors (Ki = 74-150 nM); elicits seizures when administered intravenously in mice; effective against GABAA receptor isoforms from mice, rats, and humans

Formal name: 6-imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid, monohydrobromide

Synonyms:  Gabazine

Molecular weight: 368.2

CAS: 104104-50-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Seizure Disorders

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