A potent inhibitor of ROCK-II and ROCK-I in enzyme and cell-based assays (IC50s = 3 and 56 nM

SR 3677 – 5 mg

Brand:
Cayman
CAS:
1072959-67-1
Storage:
-20
UN-No:
Non-Hazardous - /

SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK-II than ROCK-I in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively).{27385} At 3 µM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50% inhibition.{27385} SR 3677 is efficacious at inhibiting myosin light chain phosphorylation and increasing aqueous humor outflow in porcine eyes in an ex vivo model of glaucoma treatment.{27385}  

 

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Description

A potent inhibitor of ROCK-II and ROCK-I in enzyme and cell-based assays (IC50s = 3 and 56 nM, respectively); efficacious at inhibiting myosin light chain phosphorylation and increasing aqueous humor outflow in porcine eyes in an ex vivo model of glaucoma treatment

Formal name: N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide

Synonyms: 

Molecular weight: 408.5

CAS: 1072959-67-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|ROCK||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cytoskeleton & Motor Proteins||Research Area|Neuroscience|Ophthalmology

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