An inverse agonist of PPARγ (IC50 = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of FABP4 in differentiating murine preadipocytes; promotes osteogenesis in cultured human MSCs

SR 2595 – 5 mg

Brand:
Cayman
CAS:
1415252-61-7
Storage:
-20
UN-No:
Non-Hazardous - /

SR 2595 is an inverse agonist of PPARγ (IC50 = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of the adipogenic marker fatty acid-binding protein 4 in differentiating murine preadipocytes.{29288} Repression of PPARγ with SR 2595 promotes osteogenesis, as measured by calcium phosphatase deposition, in cultured human mesenchymal stem cells (MSCs).{29288} SR 2595 also increases expression of bone morphogenetic proteins BMP2 and BMP6 in MSCs.{29288}  

 

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Description

An inverse agonist of PPARγ (IC50 = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of FABP4 in differentiating murine preadipocytes; promotes osteogenesis in cultured human MSCs

Formal name: 4′-[[5-[[[(1S)-1-[4-(1,1-dimethylethyl)phenyl]ethyl]amino]carbonyl]-2,3-dimethyl-1H-indol-1-yl]methyl]-[1,1′-biphenyl]-2-carboxylic acid

Synonyms: 

Molecular weight: 558.7

CAS: 1415252-61-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Endocrinology & Metabolism|Bone Growth & Remodeling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs

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