Selectively binds RORγ (Ki = 105 nM)

SR 2211 – 5 mg

Brand:
Cayman
CAS:
1359164-11-6
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the differentiation of pro-inflammatory TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.{19869,19493} SR 2211 selectively binds RORγ (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORγ activity (IC50 = 320 nM).{21866} It has minimal effects on RORα, LXRα, and FXR activities. SR 2211 significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 μM.{21866}  

 

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SKU: 11972 - 5 mg Category:

Description

Selectively binds RORγ (Ki = 105 nM), acting as an inverse agonist of constitutive in vitro RORγ activity (IC50 = 320 nM); significantly inhibits gene expression of IL-17 and IL-23 receptor in activated EL-4 mouse T lymphocytes when given at 5 μM

Formal name: 2-fluoro-4’-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-α,α-bis(trifluoromethyl)-[1,1’-biphenyl]-4-methanol

Synonyms: 

Molecular weight: 527.5

CAS: 1359164-11-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Inverse Agonists||Research Area|Immunology & Inflammation|Adaptive Immunity

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