A non-agonist PPARγ ligand (Ki = 10 nM) which blocks Cdk5-mediated phosphorylation; does not inhibit activation of PPARγ by rosiglitazone

SR 1824 – 10 mg

Brand:
Cayman
CAS:
1338259-06-5
Storage:
-20
UN-No:
Non-Hazardous - /

Peroxisome proliferator-activated receptor γ (PPARγ) is activated by the anti-diabetes drugs known as thiazolidinediones, including rosiglitazone (Item No. 71740) and pioglitazone (Item No. 71745).{8461} Phosphorylation of PPARγ by cyclin-dependent kinase 5 (Cdk5) causes dysregulation of genes whose expression is altered in obesity, including adiponectin.{18956} SR 1824 is a non-agonist PPARγ ligand (Ki = 10 nM) which blocks Cdk5-mediated phosphorylation.{20015} It does not inhibit activation of PPARγ by rosiglitazone (Item No. 71740).{20015}  

 

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SKU: 11087 - 10 mg Category:

Description

A non-agonist PPARγ ligand (Ki = 10 nM) which blocks Cdk5-mediated phosphorylation; does not inhibit activation of PPARγ by rosiglitazone

Formal name: (S)-4′-((5-((1-(4-bromophenyl)ethyl)carbamoyl)-2,3-dimethyl-1H-indol-1-yl)methyl)-[1,1′-biphenyl]-2-carboxylic acid

Synonyms: 

Molecular weight: 581.5

CAS: 1338259-06-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Signaling||Research Area|Endocrinology & Metabolism|Hormones & Receptors|PPARs

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