A dual-site covalent antagonist of PPARγ; inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells at 5 μM; reduces basal activity of PPARγ and inhibits binding of DHA to PPARγ in a TR-FRET assay

SR 16832 – 10 mg

Brand:
Cayman
CAS:
2088135-12-8
Storage:
-20
UN-No:
Non-Hazardous - /

SR 16832 is a dual-site covalent antagonist of peroxisome proliferator-activated receptor γ (PPARγ).{42885} It inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells when used at a concentration of 5 μM. SR 16832 also reduces basal activity of PPARγ and inhibits binding of docosahexaenoic acid (DHA; Item No. 90310) to PPARγ in a time-resolved FRET (TR-FRET) assay.  

 

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Description

A dual-site covalent antagonist of PPARγ; inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells at 5 μM; reduces basal activity of PPARγ and inhibits binding of DHA to PPARγ in a TR-FRET assay

Formal name: 2-chloro-N-(6-methoxy-4-quinolinyl)-5-nitro-benzamide

Synonyms: 

Molecular weight: 357.7

CAS: 2088135-12-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Allosteric Modulators||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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