A hypocholesterolemic compound that promotes the degradation of HMG-CoA reductase in various animal models; human and rabbit pregnane X receptor agonist (Kd = 41 nM; EC50 = 137 nM for hPXR in vitro) that can induce CYP3A expression in human and rabbit hepatocytes

SR-12813 – 50 mg

Brand:
Cayman
CAS:
126411-39-0
Storage:
22
UN-No:
Non-Hazardous - /

SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity by enhancing the degradation of HMG-CoA reductase in various animal models.{30243} SR-12813 is also a high affinity ligand for human and rabbit pregnane X receptors (Kd = 41 nM; EC50 = 137 nM for hPXR in vitro) and can induce cytochrome P450 3A expression in human and rabbit hepatocytes.{30246,30245,30244}  

 

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Description

A hypocholesterolemic compound that promotes the degradation of HMG-CoA reductase in various animal models; human and rabbit pregnane X receptor agonist (Kd = 41 nM; EC50 = 137 nM for hPXR in vitro) that can induce CYP3A expression in human and rabbit hepatocytes

Formal name: P,​P’-​[[3,​5-​bis(1,​1-​dimethylethyl)​-​4-​hydroxyphenyl]​ethenylidene]​bis-phosphonic acid P,​P,​P’,​P’-​tetraethyl ester

Synonyms:  GW 485801

Molecular weight: 504.5

CAS: 126411-39-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Endocrinology & Metabolism

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