A synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE; significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 µM)

SR 11302 – 10 mg

Brand:
Cayman
CAS:
160162-42-5
Storage:
-20
UN-No:
Non-Hazardous - /

The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE.{24737} Alternatively, retinoid receptors interact with and modulate other transcription factors, including activator protein-1 (AP-1).{24737} SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE.{28072} It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 µM).{28073} SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.{28074,28075}  

 

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Description

A synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE; significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 µM)

Formal name: (2E,4E,6Z,8E)-3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid

Synonyms: 

Molecular weight: 376.5

CAS: 160162-42-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cancer

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