A phthalide antibacterial agent; strong anti-H. pylori effect (MIC = 0.2 µg/cm3); 1-40 µM inhibits LoVo and HL-60 cell proliferation

Spirolaxine – 500 µg

Brand:
Cayman
CAS:
126382-01-2
Storage:
-20
UN-No:
Non-Hazardous - /

Spirolaxine is a long-chain phthalide produced by the fungus S. laxum that has antibacterial properties.{34604,34610} Spirolaxine is a potent anti-H. pylori agent (MIC = 0.2 µg/cm3) with weak activity against E. coli.{34610,34608} Spirolaxine (1-40 µM) inhibits proliferation of endothelial (BMEC, HUVEC) and tumor (LoVo, HL-60) cells in culture.{34607} B. megaterium and C. echinulate produce hydroxylated metabolites of spirolaxine when given spirolaxine as a substrate.{34605}  

 

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Description

A phthalide antibacterial agent; strong anti-H. pylori effect (MIC = 0.2 µg/cm3); 1-40 µM inhibits LoVo and HL-60 cell proliferation

Formal name: 5-hydroxy-7-methoxy-3R-[5-[(2R,5R,7R)-2-methyl-1,6-dioxaspiro[4.5]dec-7-yl]pentyl]-1(3H)-isobenzofuranone

Synonyms: 

Molecular weight: 404.5

CAS: 126382-01-2

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Angiogenesis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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