SPD-304 – 1 mg

Brand:
Cayman
CAS:
869998-49-2
Storage:
-20
UN-No:
Non-Hazardous - /

Tumor necrosis factor α (TNFα) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis.{5958, 5957, 11088} TNFα functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. {6769, 7215} SPD-304 is an inhibitor of tumor necrosis factor α (TNFα). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM.{13640} It binds to the biologically active TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNFα-mediated stimulation of IKB degradation with an IC50 of 4.6 µM.{13640}  

 

Available on backorder

SKU: 10008012 - 1 mg Category:

Description

An inhibitor of TNF-a that prevents binding to the TNFR1 (IC50 = 22 µM)


Formal name: 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-4H-1-benzopyran-4-one

Synonyms: 

Molecular weight: 547.6

CAS: 869998-49-2

Purity: ≥98%

Formulation: A crystalline solid


Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Immunology & Inflammation