An iron chelator and derivative of desferrothiocin; induces iron excretion in rat bile and urine at 300 μmol/kg (ICE = 26.7%); decreases iron levels in rat liver and heart at 384 μmol/kg per day; induces iron excretion in iron-overloaded C. apella monkeys at 75 μmol/kg (ICE = 26.3%)

SP 420 – 10 mg

Brand:
Cayman
CAS:
911714-45-9
Storage:
-20
UN-No:
Non-Hazardous - /

SP 420 is an iron chelator and a derivative of desferrothiocin.{47683} It induces iron excretion in rat bile and urine with an iron-clearing efficiency (ICE) value of 26.7% when administered at a dose of 300 μmol/kg and decreases iron levels in rat liver and heart at 384 μmol/kg per day. SP 420 (75 μmol/kg) also induces iron excretion in iron-overloaded C. apella monkeys (ICE = 26.3%).  

 

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Description

An iron chelator and derivative of desferrothiocin; induces iron excretion in rat bile and urine at 300 μmol/kg (ICE = 26.7%); decreases iron levels in rat liver and heart at 384 μmol/kg per day; induces iron excretion in iron-overloaded C. apella monkeys at 75 μmol/kg (ICE = 26.3%)

Formal name: (4S)-4,5-dihydro-2-[2-hydroxy-4-[2-(2-methoxyethoxy)ethoxy]phenyl]-4-methyl-4-thiazolecarboxylic acid

Synonyms:  (S)-4′-(HO)-DADFT-norPE

Molecular weight: 355.4

CAS: 911714-45-9

Purity: ≥98%

Formulation: A crystalline solid

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