A β-AR antagonist (IC50s = 8.9 and 5.2 μM for β1- and β2-ARs

Sotalol (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
959-24-0
Storage:
-20
UN-No:
Non-Hazardous - /

Sotalol is a non-selective antagonist of β-adrenergic receptors (β-ARs; IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent.{26305,48449} It decreases delayed outward potassium currents (IK) in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles when used at a concentration of 100 μM.{45726} Sotalol decreases heart rate and increases blood pressure and the cardiac functional refractory period (FRP) in a canine model of ventricular tachycardia induced by programmed electrical stimulation (PES).{26305} Formulations containing sotalol have been used in the treatment of ventricular arrhythmias and maintenance of normal sinus rhythm in patients with atrial fibrillation or flutter (AFIB/AFL).  

 

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Description

A β-AR antagonist (IC50s = 8.9 and 5.2 μM for β1- and β2-ARs, respectively) and a class III antiarrhythmic agent; decreases IK in guinea pig ventricular cells and prolongs action potential duration in electrically stimulated isolated guinea pig papillary muscles at 100 μM; decreases heart rate and increases blood pressure and the cardiac FRP in a canine model of PES-induced ventricular tachycardia

Formal name: N-[4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]-methanesulfonamide, monohydrochloride

Synonyms:  (±)-Sotalol|DL-Sotalol|MJ1999

Molecular weight: 308.8

CAS: 959-24-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Heart|Arrhythmia

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