A selective D4 receptor antagonist (Kis = 10 nM); selective over D1

Sonepiprazole – 10 mg

Brand:
Cayman
CAS:
170858-33-0
Storage:
-80
UN-No:
Non-Hazardous - /

Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM).{34143,34145} Its safety profile in rat studies is improved in comparison to classical antipsychotics but it is not effective for positive or negative symptoms of schizophrenia in patients.{34143,34142} In a pharmacological model of stress exposure in rhesus monkeys, sonepiprazole reverses stress-induced cognitive deficits.{34141}  

 

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SKU: 11983 - 10 mg Category:

Description

A selective D4 receptor antagonist (Kis = 10 nM); selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM),

Formal name: 4-[4-[2-[(1S)-3,4-dihydro-1H-2-benzopyran-1-yl]ethyl]-1-piperazinyl]-benzenesulfonamide

Synonyms:  PNU 101387|U-101387

Molecular weight: 401.5

CAS: 170858-33-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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