A macrolide antibiotic; active against Gram-positive and Gram-negative bacteria

Solithromycin – 10 mg

Brand:
Cayman
CAS:
760981-83-7
Storage:
-20
UN-No:
Non-Hazardous - /

Solithromycin is a macrolide antibiotic with activity against Gram-positive and Gram-negative bacteria, including C. trachomatis and C. pneumoniae (MICs = 0.125-0.5 and 0.25-1 μg/ml, respectively).{37272} It also inhibits growth of multidrug resistant P. falciparum in vitro (IC50s = 0.5 nM for both Dd2 and 7G8 strains).{37273} Solithromycin (100 mg/kg) administered in a four-dose series eradicates P. berghei infection in mice. Formulations containing solithromycin are under clinical investigation for the treatment of otitis and respiratory tract infections as well as non-alcoholic steatohepatitis (NASH).  

 

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Description

A macrolide antibiotic; active against Gram-positive and Gram-negative bacteria, including C. trachomatis and C. pneumoniae (MICs = 0.125-0.5 and 0.25-1 μg/ml, respectively); inhibits growth of multidrug resistant P. falciparum in vitro (IC50s = 0.5 nM for both Dd2 and 7G8 strains); eradicates P. berghei infection in mice when administered in a four-dose series at 100 mg/kg

Formal name: (3aS,4R,7S,9R,10R,11R,13R,15R,15aR)-1-[4-[4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl]butyl]-4-ethyl-7-fluorooctahydro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-2H-oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(1H,7H,9H)-tetrone

Synonyms: 

Molecular weight: 845

CAS: 760981-83-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics|Macrolides||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Pneumonia||Research Area|Infectious Disease|Bacterial Diseases|STDs||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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