A muscarinic M1

Solifenacin (succinate) – 25 mg

Brand:
Cayman
CAS:
242478-38-2
Storage:
-20
UN-No:
Non-Hazardous - /

Solifenacin is a competitive antagonist of M1, M2, and M3 muscarinic acetylcholine receptors (Kis = 25, 125, and 10 nM, respectively, for the human receptors).{28353} It inhibits calcium mobilization induced by carbachol (carbamoylcholine; Item No. 14486) in isolated guinea pig detrusor muscle cells (Ki = 4 nM).{48902} Solifenacin inhibits carbachol-induced contraction of isolated guinea pig urinary bladder smooth muscle. In vivo, solifenacin (0.03-1 mg/kg) inhibits carbachol-induced increases in urinary bladder pressure in anesthetized rats. Formulations containing solifenacin have been used in the treatment of overactive bladder.  

 

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Description

A muscarinic M1, M2, and M3 receptor antagonist (Kis = 25, 125, and 10 nM, respectively, for the human receptors); inhibits carbachol-induced calcium mobilization in isolated guinea pig detrusor muscle cells (Ki = 4 nM); inhibits carbachol-induced contraction of isolated guinea pig urinary bladder smooth muscle; inhibits carbachol-induced increases in urinary bladder pressure in anesthetized rats from 0.03-1 mg/kg

Formal name: (1S)-(3R)-1-azabicyclo[2.2.2]oct-3-yl 3,4-dihydro-1-phenyl-2(1H)-isoquinolinecarboxylate, butanedioic acid

Synonyms:  Isoprenalinoe sulfate|YM-67905

Molecular weight: 480.6

CAS: 242478-38-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience

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