A short-chain fatty acid; produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk; an HDAC inhibitor (IC50 = 90 µM in a cell-free assay); induces differentiation

Sodium Butyrate – 100 g

Brand:
Cayman
CAS:
156-54-7
Storage:
22
UN-No:
Non-Hazardous - /

Sodium butyrate is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.{52278,52279} Sodium butyrate is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay).{52280} It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.{52279,52281,17300,52282} Sodium butyrate decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.{17300} It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.{52281} Sodium butyrate also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.{52283}  

 

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Description

A short-chain fatty acid; produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk; an HDAC inhibitor (IC50 = 90 µM in a cell-free assay); induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells from 0.6-100 mM; decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells at 2 mM; reduces tumor growth in a CaSki mouse xenograft model at 200 and 800 mg/kg per day; reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis

Formal name: butanoic acid, sodium salt

Synonyms:  Butyric Acid

Molecular weight: 110.1

CAS: 156-54-7

Purity: ≥95% (NMR)

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Immunology & Inflammation|Gastric Disease|Ulcerative Colitis||Research Area|Lipid Biochemistry|Fatty Acids

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