A chemical chaperone that has been shown to rescue the trafficking of misfolded proteins; an HDAC inhibitor (IC50 = 0.4 mM); induces cell cycle arrest

Sodium 4-Phenylbutyrate – 10 g

Brand:
Cayman
CAS:
1716-12-7
Storage:
-20
UN-No:
Non-Hazardous - /

Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.{23406,23405} It also weakly blocks histone deacetylase activity (IC50 = 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.{17643,23404} Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.{23403}  

 

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SKU: 11323 - 10 g Category:

Description

A chemical chaperone that has been shown to rescue the trafficking of misfolded proteins; an HDAC inhibitor (IC50 = 0.4 mM); induces cell cycle arrest, differentiation, and/or apoptosis of various tumors,

Formal name: benzenebutanoic acid, monosodium salt

Synonyms:  Benzenebutanoic Acid|NSC 657802|TriButyrate

Molecular weight: 186.2

CAS: 1716-12-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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