An inhibitor of BTK (IC50s = 4.6 and 1.1 nM for wild-type and BTKC481S

SNS-062 – 25 mg

Brand:
Cayman
CAS:
1270014-40-8
Storage:
-20
UN-No:
Non-Hazardous - /

SNS-062 is an inhibitor of Bruton’s tyrosine kinase (BTK; IC50s = 4.6 and 1.1 nM for wild-type and BTKC481S, respectively).{53166} It also binds to IL2-inducible T cell kinase (Itk; Kd = 2.2 nM) and nine other kinases (Kds = 50 value of 50 nM. It inhibits BTK phosphorylation in B cells isolated from the whole blood of patients with chronic lymphocytic leukemia in a dose-dependent manner.{53166}  

 

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SKU: 29200 - 25 mg Category:

Description

An inhibitor of BTK (IC50s = 4.6 and 1.1 nM for wild-type and BTKC481S, respectively); binds to Itk (Kd = 2.2 nM) and nine other kinases (Kds = 50 = 50 nM); inhibits BTK phosphorylation in B cells isolated from the whole blood of patients with chronic lymphocytic leukemia in a dose-dependent manner

Formal name: 2-[(3-chlorophenyl)amino]-N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3-piperidinyl]-acetamide

Synonyms: 

Molecular weight: 384.9

CAS: 1270014-40-8

Purity: ≥98%

Formulation: A crystalline solid

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