The active metabolite of irinotecan that potently inhibits DNA topoisomerase I; more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM)

SN-38 – 10 mg

Brand:
Cayman
CAS:
86639-52-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

SN-38 is the active metabolite of irinotecan (Item No. 14180), a derivative of the alkaloid camptothecin (Item No. 11694), and acts as a potent inhibitor of DNA topoisomerase I.{21114,21115} It is formed by the hydrolysis of irinotecan by carboxylesterases and metabolized through glucuronidation by UDP glucuronosyl transferase 1A1.{22661,22662} SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM).{21114,21115}  

 

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Description

The active metabolite of irinotecan that potently inhibits DNA topoisomerase I; more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM)

Formal name: 4,11-diethyl-4,9-dihydroxy-(4S)-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Synonyms:  7-ethyl-10-hydroxy-20(S)-Camptothecin|7-Ethyl-10-Hydroxycamptothecin|NK 012

Molecular weight: 392.4

CAS: 86639-52-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair

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