A selective inhibitor of SCFMET30 ubiquitin ligase

SMER3 – 50 mg

Brand:
Cayman
CAS:
67200-34-4
Storage:
-20
UN-No:
Non-Hazardous - /

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response.{25205,25204} It is a small molecule enhancer of rapamycin (Item No. 13346), in that it enhances yeast cell lethality in response to rapamycin.{25205} SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4.{25205} As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.{25203}  

 

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Description

A selective inhibitor of SCFMET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response; at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4

Formal name: 9H-indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one

Synonyms:  MET30 Antagonist|SCFMET30 Inhibitor

Molecular weight: 224.2

CAS: 67200-34-4

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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