An enhancer of autophagy; increases autophagosome synthesis and enhances clearance of aggregate-prone substrates

SMER28 – 5 mg

Brand:
Cayman
CAS:
307538-42-7
Storage:
-20
UN-No:
Non-Hazardous - /

SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases.{31378,31377,31379} SMER28 induces clearance of amyloid-β (Aβ) peptides and the amyloid precursor protein c-terminal fragment (APP-CTF) in mouse embryonic fibroblasts (MEFs) isolated from wild-type, but not autophagy-related protein 5 knockout (Atg5-/-), mouse embryos in a concentration-dependent manner.{41265} It induces autophagy independently of rapamycin (Item No. 13346) in mammalian cells at a concentration of 47 µM.{31378} SMER28 also promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents.{31158}  

 

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Description

An enhancer of autophagy; increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington’s, Parkinson’s, and Alzheimer’s diseases; induces clearance of Aβ peptides and APP-CTF in MEFs isolated from wild-type, but not Atg5-/-, mouse embryos in a concentration-dependent manner; induces autophagy independently of rapamycin in mammalian cells at a concentration of 47 µM; promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents

Formal name: 6-bromo-N-2-propen-1-yl-4-quinazolinamine

Synonyms: 

Molecular weight: 264.1

CAS: 307538-42-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy||Research Area|Cell Biology|Stem Cell Research|Reprogramming||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Huntington’s Disease||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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