A heterobifunctional cross-linking reagent containing an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in click chemistry reactions in the conjugation of proteins; has been used to cross-link mertansine to an IgG1 monoclonal antibody to form the antibody-drug conjugate DM1-SMCC; immunization of mice with SMCC-coupled keyhole limpet hemocyanin (KLH) antigen and syngeneic splenocytes increases the percentage of proliferating T cells in isolated splenocytes from recipient mice compared to mice immunized with KLH and the adjuvant LPS.

SMCC – 25 mg

Brand:
Cayman
CAS:
64987-85-5
Storage:
-20
UN-No:
Non-Hazardous - /

SMCC is a heterobifunctional cross-linking reagent that contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in click chemistry reactions in the conjugation of proteins.{45649,45650,45651} It has been used to cross-link the anticancer agent DM1 (mertansine; Item No. 22483) to an IgG1 monoclonal antibody to form the antibody-drug conjugate DM1-SMCC (Item No. 23926).{35225} Immunization of mice with SMCC-coupled keyhole limpet hemocyanin (KLH) antigen and syngeneic splenocytes increases the percentage of proliferating T cells in isolated splenocytes from recipient mice compared to mice immunized with KLH and the adjuvant LPS.{45651}  

 

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SKU: 28955 - 25 mg Category:

Description

A heterobifunctional cross-linking reagent containing an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in click chemistry reactions in the conjugation of proteins; has been used to cross-link mertansine to an IgG1 monoclonal antibody to form the antibody-drug conjugate DM1-SMCC; immunization of mice with SMCC-coupled keyhole limpet hemocyanin (KLH) antigen and syngeneic splenocytes increases the percentage of proliferating T cells in isolated splenocytes from recipient mice compared to mice immunized with KLH and the adjuvant LPS.

Formal name: 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-cyclohexanecarboxylic acid, 2,5-dioxo-1-pyrrolidinyl ester

Synonyms:  NSC 344483|Succinimidyl 4-(N-maleimidomethyl)cyclohexan-1-carboxylate

Molecular weight: 334.3

CAS: 64987-85-5

Purity: ≥98%

Formulation: A solid

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