A TLR7 agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor); selective for TLR7 over TLR8 (EC50 = >10 µM); induces IFN production in isolated human PBMCs (MEC = 10 nM); induces proliferation of isolated mouse

SM-324405 – 10 mg

Brand:
Cayman
CAS:
677773-91-0
Storage:
-20
UN-No:
Non-Hazardous - /

SM-324405 is a toll-like receptor 7 (TLR7) agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor).{53555} It is selective for TLR7 over TLR8 (EC50 = >10 µM). SM-324405 induces IFN production in isolated human peripheral blood mononuclear cells (PBMCs) with a minimum effective concentration (MEC) of 10 nM. It induces proliferation of isolated mouse, rat, and dog splenocytes (EC50s = 3.98, 6.31, and 12.59 nM, respectively).{53556} SM-324405 (0.1 and 1 mg/kg, intratracheally) inhibits bronchoalveolar lavage fluid (BALF) eosinophil infiltration in a rat model of ovalbumin-sensitized and -challenged allergic airway inflammation.{53555}  

 

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SKU: 29457 - 10 mg Category:

Description

A TLR7 agonist (EC50 = 50.1 nM in a reporter assay using HEK293 cells expressing the human receptor); selective for TLR7 over TLR8 (EC50 = >10 µM); induces IFN production in isolated human PBMCs (MEC = 10 nM); induces proliferation of isolated mouse, rat, and dog splenocytes (EC50s = 3.98, 6.31, and 12.59 nM, respectively); inhibits BALF eosinophil infiltration in a rat model of ovalbumin-sensitized and -challenged allergic airway inflammation,,

Formal name: 3-[(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)methyl]-benzeneacetic acid, methyl ester

Synonyms: 

Molecular weight: 385.4

CAS: 677773-91-0

Purity: ≥95%

Formulation: A crystalline solid

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