Description
A cell-permeable Smac mimetic and an inhibitor of XIAP; binds to BIR2 and BIR3 domain-containing XIAP (IC50 = 1.39 nM); inhibits growth (IC50 = 1 nM), as well as activates caspase-3 and caspase-9, and induces cleavage of PARP in HL-60 leukemia cells at 10 nM; reduces tumor volume by 80% in a 2LMP breast cancer mouse xenograft model at 5 mg/kg in combination with TRAIL
Formal name: (3S,3′S,6S,6′S,10aS,10′aS)-N,N′-[1,4-phenylenebis[4,1-butanediyl-1H-1,2,3-triazole-1,4-diyl[(S)-phenylmethylene]]]bis[decahydro-6-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-5-oxo-pyrrolo[1,2-a]azocine-3-carboxamide
Synonyms:
Molecular weight: 1,121.40
CAS: 957135-43-2
Purity: ≥95%
Formulation: A solid
