A potent and selective SPHK1 inhibitor (Kis = 0.048 and >10 μM for SPHK1 and 2

SLP7111228 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1449768-48-2
Storage:
-20
UN-No:
Non-Hazardous - /

SLP7111228 is a potent and selective inhibitor of sphingosine kinase (SPHK) 1 with Ki values of 0.048 and >10 μM for SPHK1 and 2, respectively.{38636} It induces a concentration-dependent decrease in sphingosine-1-phosphate (S1P; Item No. 62570) in U937 cells but has no effect on sphingosine levels. In vivo, SLP7111228 decreases blood levels of S1P in a dose-dependent manner in rats.  

 

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SKU: 23290 - 10 mg Category:

Description

A potent and selective SPHK1 inhibitor (Kis = 0.048 and >10 μM for SPHK1 and 2, respectively); induces a concentration-dependent decrease in U937 cells; decreases blood levels of S1P in a dose-dependent manner in rats,

Formal name: (2S)-2-[[3-(4-octylphenyl)-1,2,4-oxadiazol-5-yl]methyl]-1-pyrrolidinecarboximidamide, monohydrochloride

Synonyms: 

Molecular weight: 420

CAS: 1449768-48-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area

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