Description
A dual SPHK1 and SPHK2 inhibitor (Kis = 0.73 and 0.9 µM, respectively, using human recombinant kinases); selective for Sphk2 over Sphk1 in mice (Kis = 1 and 20 µM, respectively); not selective in rat (Kis = 1.1 and 0.8 µM for Sphk2 and Sphk1, respectively); decreases S1P in vitro at concentrations of 0.1 and 0.3 µM; decreases S1P in Sphk1-/- knockout mice and in rat at a dose of 10 mg/kg
Formal name: (2S,3S)-3-hydroxy-2-[3-[6-(pentyloxy)-2-naphthalenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide, monohydrochloride
Synonyms:
Molecular weight: 445.9
CAS: 1870811-01-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Other Lipid Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Lipid Biochemistry|Sphingolipids
