A prodrug of gemcitabine designed for improved oral bioavailability; inhibits the growth of human non-small cell lung cancer NCI-H460 cells

SL 01 – 1 g

Brand:
Cayman
CAS:
26049-94-5
Storage:
-20
UN-No:
De Minimis - 3261 / 8

SL 01 is a prodrug of gemcitabine (Item No. 11690), the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability.{24479} SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis.{24480,24481} In nude mice bearing NCI-H460, HCT116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.{24480,24481}  

 

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Description

A prodrug of gemcitabine designed for improved oral bioavailability; inhibits the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT116 cells, and breast cancer MCF-7 cells both in vitro (IC50s = 0.78, 0.92, and 0.64 μM, respectively) and in xenograft cancer models

Formal name: N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-carbamic acid, phenylmethyl ester

Synonyms:  NSC 251810

Molecular weight: 331.8

CAS: 26049-94-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair

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