A fungal metabolite which interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor; reduces both glucagon-stimulated cAMP production and glycogenolysis at 10 μM

Skyrin – 1 mg

Brand:
Cayman
CAS:
602-06-2
Storage:
-20
UN-No:
Non-Hazardous - /

Skyrin is a fungal metabolite characterized by a bisanthraquinone structure. It interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor.{21666} At 10 μM, skyrin reduces both glucagon-stimulated cAMP production and glycogenolysis.{21666} It does not interfere with epinephrine or glucagon-like peptide 1 effects on these parameters.{21666}  

 

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Description

A fungal metabolite which interferes with glucagon signaling through adenylate cyclase without binding to the glucagon receptor; reduces both glucagon-stimulated cAMP production and glycogenolysis at 10 μM

Formal name: 2,2′,4,4′,5,5′-hexahydroxy-7,7′-dimethyl-[1S,1′-bianthracene]-9,9′,10,10′-tetrone

Synonyms:  Endothianin|Rhodophyscin

Molecular weight: 538.5

CAS: 602-06-2

Purity: ≥97%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Anthraquinones||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cell Biology|Cell Signaling|cAMP Signaling||Research Area|Endocrinology & Metabolism|Carbohydrate Metabolism

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