An inhibitor of Skp2-mediated p27 degradation; blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro at 50 μM; increases nuclear accumulation of p27 in ECC-1 endometrial carcinoma cells

SKPin C1 – 10 mg

Brand:
Cayman
CAS:
432001-69-9
Storage:
-20
UN-No:
Non-Hazardous - /

SKPin C1 is an inhibitor of Skp1-Cullin1-F-box (SCF) family protein Skp2-mediated p27 degradation.{45107} It binds to Skp2 at the Cdc kinase subunit 1 (Cks1) interaction interface and blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro when used at a concentration of 50 μM. SKPin C1 increases nuclear accumulation of p27 in ECC-1 endometrial carcinoma cells.{45108}  

 

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SKU: 26141 - 10 mg Category:

Description

An inhibitor of Skp2-mediated p27 degradation; blocks ubiquitylation of p27 in a Cks1-dependent manner in vitro at 50 μM; increases nuclear accumulation of p27 in ECC-1 endometrial carcinoma cells

Formal name: 2-[4-bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]-acetic acid

Synonyms: 

Molecular weight: 465.3

CAS: 432001-69-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cancer||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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