A widely used

SKF 525A (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
62-68-0
Storage:
-20
UN-No:
Non-Hazardous - /

SKF 525A is a widely used, nonspecific cytochrome P (CYP)450 inhibitor that demonstrates 100% inhibition of the various CYP450 isoforms at 1-100 μM.{24114} It therefore potentiates the effects of many different drugs by inhibiting their metabolism (IC50 values in the μM range when tested using human liver microsomes).{24115} SKF 525A inhibits CYP450-dependent arachidonic acid conversion to active EET metabolites, antagonizing the recovery of functional calcium pools.{5318} It also acts as a noncompetitive inhibitor of acetylcholine nicotinic receptors (IC50 = 19 μM in mouse skeletal muscle).{9025,24116}  

 

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Description

A widely used, nonspecific CYP450 inhibitor that potentiates the effects of many different different drugs by inhibiting their metabolism (IC50 values in the μM range when tested using human liver microsomes); also acts as a noncompetitive inhibitor of acetylcholine nicotinic receptors

Formal name: α-phenyl-α-propyl-benzeneacetic acid, 2-(diethylamino)ethyl ester, monohydrochloride

Synonyms:  RP 5171|U 5446

Molecular weight: 390

CAS: 62-68-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area

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