A broad-spectrum aminoglycoside antibiotic; active against Gram-positive and Gram-negative bacteria including B. subtilis

Sisomicin – 1 g

Brand:
Cayman
CAS:
32385-11-8
Storage:
-20
UN-No:
Non-Hazardous - /

Sisomicin is a broad-spectrum aminoglycoside antibiotic originally isolated from M. inyoensis.{42272} It is active against Gram-positive and Gram-negative bacteria including B. subtilis, S. aureus, E. coli, and P. aeruginosa among others (MICs = 0.01-0.75 µg/ml) but is less active against P. multocida and V. coli (MICs = 7.5 and 2.4 µg/ml, respectively). Sisomicin is protective against Gram-positive and Gram-negative bacterial infections in mice with 50% protective dose (PD50s) values ranging from 0.5 to 6 mg/kg.  

 

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Description

A broad-spectrum aminoglycoside antibiotic; active against Gram-positive and Gram-negative bacteria including B. subtilis, S. aureus, E. coli, and P. aeruginosa, among others (MICs = 0.01-0.75 µg/ml); protective against Gram-positive and Gram-negative bacterial infections in mice (PD50s = 0.5-6 mg/kg)

Formal name: O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-D-streptamine

Synonyms:  Antibiotic 6640|SCH 13475

Molecular weight: 447.5

CAS: 32385-11-8

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Aminoglycosides||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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