A cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases

Sirtinol – 25 mg

Brand:
Cayman
CAS:
410536-97-9
Storage:
-20
UN-No:
Non-Hazardous - /

Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 μM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 μM, respectively.{15174} It does not alter HDAC1 activity.{15174} Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells.{20764,20761,20763} In plants, sirtinol can be metabolized to 2-hydroxy-1-naphthoic acid, which activates auxin signaling and alters plant growth and development.{20765,20762}  

 

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SKU: 10523 - 25 mg Category:

Description

A cell-permeable inhibitor of sirtuin NAD+-dependent deacetylases, inhibiting the yeast sirtuin Sir2p with an IC50 value of 68 μM and the human sirtuins SIRT1 and SIRT2 with IC50 values of 131 and 38 μM, respectively; does not alter HDAC1 activity

Formal name: 2-[[(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-benzamide

Synonyms:  Sir Two Inhibitor Naphthol

Molecular weight: 394.5

CAS: 410536-97-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation||Research Area|Immunology & Inflammation

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