Key Features Specially formulated Single-Use Linoleic Acid (peroxide free) for use in cell culture or other in vitro experiments Peroxide free and sealed under argon to maintain product integrity Each pack contains 10 single-use ampules (>1 ml fatty acid at 500 µg/ml in ethanol) Single-use linoleic acid (peroxide free) consists of 10 sealed ampules, each containing >1 ml of ethanolic solution of fatty acid at a concentration of 500 µg/ml. Peroxides were removed by silicic acid chromatography. The headspace in each ampule is purged with argon. Single-use polyunsaturated fatty acids (PUFAs) are intended for analytical and research applications where absence of oxidized adducts is desired. Ampules have been optimized for one-time use. For best results, use promptly after opening. Linoleic acid (Item No. 90150) is a PUFA that is prevalent in the western diet. PUFAs, including linoleic acid, oxidize spontaneously on exposure to room air, yielding a complex mixture of fatty acid peroxides. Oxidation of PUFAs can be particularly problematic in samples stored in capped vials for prolonged periods, even at low temperatures. These single-use ampules are designed to circumvent this issue.
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An ethanolic solution in sealed ampules with the headspace purged with argon
Formal name: 9Z,12Z-octadecadienoic acid
Synonyms: Single-Use Telfairic Acid (peroxide free)
Molecular weight: 280.5
CAS: 60-33-3
Purity: ≥98%
Formulation: A solution in ethanol
Application|Mass Spectrometry||Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Lipids|Octadecanoids||Research Area|Lipid Biochemistry|Fatty Acids
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}
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