A nucleoside structurally related to SAH and SAM that inhibits SET domain-containing methyltransferases (IC50 values range from 0.1-20 μM)

Sinefungin – 5 mg

Brand:
Cayman
CAS:
58944-73-3
Storage:
-20
UN-No:
Non-Hazardous - /

Sinefungin is a nucleoside structurally related to S-adenosylhomocysteine (Item No. 13603) and S-adenosylmethionine (Item No. 13956) that was originally isolated from Streptomyces.{18391,18646} While it has limited use as an antibiotic due to its high in vivo toxicity, sinefungin has proved useful as a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 μM).{16624,18398,24147,18480,19368}  

 

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Description

A nucleoside structurally related to SAH and SAM that inhibits SET domain-containing methyltransferases (IC50 values range from 0.1-20 μM)

Formal name: 6,9-diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-α-L-talo-decofuranuronic acid

Synonyms:  A 9145|Antibiotic 32232RP|Antibiotic A 9145|RP 32232

Molecular weight: 381.4

CAS: 58944-73-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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