A potent

Simvastatin (sodium salt) – 1 mg

Brand:
Cayman
CAS:
101314-97-0
Storage:
-20
UN-No:
Non-Hazardous - /

Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg/day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363} Clinical formulations containing simvastatin are used in combination with ezetimibe to treat dyslipidemia.  

 

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SKU: 10010345 - 1 mg Category:

Description

A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM); 8 mg/kg/day for 18 days reduces plasma cholesterol levels by 33% in dogs; suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM),

Formal name: (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monosodium salt

Synonyms: 

Molecular weight: 458.6

CAS: 101314-97-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism

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