An internal standard for the quantification of simvastatin by GC- or LC-MS

Simvastatin-d6 – 1 mg

Brand:
Cayman
CAS:
1002347-71-8
Storage:
-20
UN-No:
Non-Hazardous - /

Simvastatin-d6 contains six deuterium atoms located on the methyl groups. It is intended for use as an internal standard for the quantification of simvastatin (Item No. 10010344) by GC- or LC-MS. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.{15312} After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.{15310} Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.{15363}  

 

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Description

An internal standard for the quantification of simvastatin by GC- or LC-MS

Formal name: 2,2-di(methyl-d3)-(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid

Synonyms: 

Molecular weight: 424.6

CAS: 1002347-71-8

Purity: ≥99% deuterated forms (d1-d6); ≤1% d0

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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