Description
A potent, competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM); 8 mg/kg/day for 18 days reduces plasma cholesterol levels by 33% in dogs; suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM) ,
Formal name: 2,2-dimethyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid
Synonyms: MK-733
Molecular weight: 418.6
CAS: 79902-63-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors
