An inhibitor of mitochondrial complex II (IC50s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria

Siccanin – 500 µg

Brand:
Cayman
CAS:
22733-60-4
Storage:
-20
UN-No:
Non-Hazardous - /

Siccanin is an inhibitor of mitochondrial complex II (succinate dehydrogenase; IC50s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively).{41290} It inhibits the growth of T. mentagrophytes (IC50 = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria.{41291} It also inhibits the growth of C. albicans strains with IC50 values ranging from 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively.{41292}  

 

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SKU: 23654 - 500 µg Category:

Description

An inhibitor of mitochondrial complex II (IC50s = 0.87 and 9.3 μM for P. aeruginosa and rat mitochondria, respectively); inhibits the growth of T. mentagrophytes (IC50 = 0.3 μg/ml) via inhibition of succinate oxidation in the mitochondria; inhibits the growth of C. albicans (IC50s = 5-40 and 80-90 μg/ml for aerobic and anaerobic conditions, respectively)

Formal name: (4aS,6aS,11bR,13aS,13bS)-2,3,4,4a,5,6,6a,13b-octahydro-4,4,6a,9-tetramethyl-1H,11bH,13H-benzo[a]furo[2,3,4-mn]xanthen-11-ol

Synonyms:  (-)-Siccanin|NSC 135048

Molecular weight: 342.5

CAS: 22733-60-4

Purity: >98%

Formulation: A solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Oxidative Phosphorylation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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