A tricyclic peptide with antiviral and antibacterial activities; active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM

Siamycin I – 1 mg

Brand:
Cayman
CAS:
164802-68-0
Storage:
-20
UN-No:
Non-Hazardous - /

Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities.{47469,47470} It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro.{47469} Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 μg/ml).{47470} Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP).{47471}  

 

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SKU: 27783 - 1 mg Category:

Description

A tricyclic peptide with antiviral and antibacterial activities; active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro; inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells (ED50 = 0.08 μM); active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 μg/ml); inhibits GBAP-induced autophosphorylation of the E. faecalis quorum sensing kinase FsrC

Formal name:

Synonyms:  BMY 29304|FR 901724

Molecular weight: 2,163.50

CAS: 164802-68-0

Purity: ≥85%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Polypeptides||Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Quorum Sensing||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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