A SRC-3 inhibitor that induces death in various breast cancer cells (IC50s = 3-20 nM) without affecting normal cell viability; inhibits primary tumor growth and reduces SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model

SI-2 – 1 mg

Brand:
Cayman
CAS:
380537-35-9
Storage:
-20
UN-No:
Non-Hazardous - /

SI-2 is an inhibitor of steroid receptor coactivator 3 (SRC-3). It has been shown to selectively reduce the transcriptional activities and the protein concentrations of SRC-3 in cells through direct physical interactions with SRC-3.{31177} SI-2 induces death in various breast cancer cells with IC50 values of 3-20 nM without affecting normal cell viability.{31177} At 2 mg/kg, SI-2 can also inhibit primary tumor growth and reduce SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model.{31177}  

 

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Description

A SRC-3 inhibitor that induces death in various breast cancer cells (IC50s = 3-20 nM) without affecting normal cell viability; inhibits primary tumor growth and reduces SRC-3 protein levels in an MDA-MB-468 breast cancer mouse model

Formal name: (1E)-1-(2-pyridinyl)-ethanone-2-(1-methyl-1H-benzimidazol-2-yl)hydrazone

Synonyms:  EPH 116

Molecular weight: 265.3

CAS: 380537-35-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Cancer|Transcription Factors

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